Endocrine Abstracts

Classic thyroid hormone resistance (THR) occurs per every 400 000 live birth. THR should be considered along with TSH-producing adenomas when normal or high levels of TSH not consistent with hyperthyroidism is present. A 45-year-old female patient who was operated three times for multinodulary goitre had been treated with L-thyroxine. Mamillary biopsy had performed after detection of mass localized in right breast by mammography performed during regular follow-u...

Introduction: Primary thyroid lymphomas are rare cancers and account 1–5% of all thyroid cancers and 3% of all extranodal non hodgkin lymphomas (NHLs). We aimed to present cases of thyroid lymphoma encountered in our clinic.Case 1: A 54-year-old female patient admitted with pain and swallow on the cervical region. In ultrasonographic (USG) thyroid examination, it was found that both thyroid lobes were very large with routh parenchyme consis...

Introduction: Thyroid hormones play an important role in achieving and maintaining reproductive functions. Thyroid dysfunction affects the menstrual cycle and often leads to menstrual irregularity. We prospectively investigated untreated female patients presenting to our Endocrinology and Internal Medicine outpatient clinics.Material and methods: All the patients were of reproductive age and were newly diagnosed with thyroid dysfunction. After a detailed...

Background: Incretin-based therapy is increasingly used in the management of type 2 diabetes mellitus. Although dipeptidyl peptidase-4 inhibitors (gliptins) are well tolerated, side effects can be observed in various body systems. Here we report three cases of drug-induced skin eruption with strong itching of the gliptins plus metformin combination therapy.Case reports: A 59-year-old woman and a 57-year-old man, who had been using vildagliptin plus metfo...

Aim: To evaluate prevalence of erectile dysfunction (ED) in patients with type 2 diabetes in relation to the cardiovascular risk factors.Methods: A total of 116 males including type 2 diabetic patients (n=68, mean age: 56.7 (5.8) years) and age-matched healthy controls (n=48, mean age: 57.0 (6.6) years) were included to study. Concomitant hypertension, hyperlipidemia, and coronary artery disease (CAD) were recorded in each subject along...

Aim: Erectile dysfunction (ED) has been reported to occur more commonly in diabetes than general population with the prevalence rate varies widely from 35 to 75%. Patients with diabetes was also shown to have much earlier onset of ED and more severe form of the disease associated with a poorer quality of life. We aimed to evaluate association of ED with diabetes related complications in patients with type 2 diabetes in our study.Methods: In a total of 68...

Background: Although very rare, insulinomas are the most commonly occurring endocrine tumor of the pancreas. The aim of this study was to review the clinical presentation, diagnostic approach and management of patients with an insulinoma.Methods: 22 insulinoma patients, with an age range of 20–79, were included and evaluated according to their clinical presentation, blood biochemistry, imaging studies, operative management, pathological manifestatio...

Objective: Vitamin D deficiency has been shown to alter insulin synthesis and secretion in both humans and animal models. However, less is known on the association between vitamin D and type 2 diabetes mellitus. In the current study we aimed to analyze the relationship between vitamin D levels with glycemic control in type 2 diabetic patients.Material and methods: Three hundred and twenty diabetic patients who are follow up at least 6 months for diabetes...

Objective: The prevalence and incidence of diabetes mellitus (DM) are increasing at all ages, including older populations. Several studies have shown that elderly diabetics have impaired cognitive function compared to age-matched non-diabetics, as well as a higher risk of dementia. In the current study we aimed to analyze relationship between microalbuminuria and cognitive dysfunction in elderly patients with type 2 diabetes.Material and Methods: One hun...

Excessive expression of CyD1 in CCND1 gene increase G1-S phase transition and cellular proliferation. In various tumor types and of the few studies of pituitary adenomas, over expression of CyD1 or amplification in the locus of CCND1 gene, have been demonstrated. In this study, we aimed to investigate the effect of cyclin D1 gene polymorphism on tumor formation in prolactinoma patients.A hundred and thirteen patients and 108 age and gender matched contro...